aMule is based on eMule and offers a more simplified and structured interface, although the main options are practically the same.
The first thing we should emphasize is that it doesn't need to be installed, so it becomes a portable application. When we run aMule we find a very similar interface, although the settings and advanced options are grouped in a different way.
We all know that sometimes we don't like how our P2P client is working and we want to try a new one, if you are thinking about the change, give it a try. It works very good and you won't be disappointed.